HPE ProLiant ML350 Gen11 4416+ 2.0GHz 20‑core 1P 32GB‑R MR408i‑o 8SFF 1000W RPS Server | P53569-421
SKU: P53569-421
£9,582.32 (Excl. VAT)
- Description
- Specifications
- Downloads
-
HPE ProLiant ML350 Gen11 4416+ 2.0GHz 20‑core 1P 32GB‑R MR408i‑o 8SFF 1000W RPS Server

Are you looking for a robust and flexible tower optimized server for your SMB and remote offices? The HPE ProLiant ML350 Gen11 is a powerful 2P tower server with optional rackable chassis for various environments, and delivers exceptional compute performance, security, reliability, and expandability. Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors up to 64 cores, up to 8 TB DDR5, PCIe Gen5, enhanced I/O and GPU support, and EDSFF storage, the HPE ProLiant ML350 Gen11 server fulfills a wide range of demanding workloads. The silicon root of trust anchors the server firmware to an HPE-exclusive ASIC, creating a fingerprint for the 4th and 5th Gen Intel Xeon Scalable processors that must be matched exactly before the server will boot. The HPE ProLiant ML350 Gen11 server is an excellent choice for diverse workloads such as IT infrastructure, Data Management, VDI, ERP/CRM. Scale and adapt to any environment with this server and accelerate your growing business.
HPE ProLiant ML350 Gen11 8 SFF server with one Intel® Xeon® Silver 4416+ processor, 32 GB DDR5 RDIMM memory, HPE MR408i-o storage controller, and one HPE 1000W Flex Slot Power Supply
Powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores (128 cores per server), 350W TDP. Increased memory bandwidth to 5600 MT/s, up to 8TB DDR5 memory capacity.
Supports new EDSFF E3.S NVMe form factor to enable higher-density servers and storage systems, optimization of PCIe lanes from CPUs, and ultra-high SSD performance.
Advanced data transfer rates from the PCIe Gen5 serial expansion bus, support up to 10 standard PCIe Gen5 slots and 2 OCP 3.0 slots .
Includes HPE Integrated Lights-Out 6 (iLO 6) server management software that enables you to securely configure, monitor, and update your HPE ProLiant Gen11 servers seamlessly from anywhere.
Supports hot-pluggable, high-availability, RAID1 protected M.2 NVMe boot option.
Support NVIDIA RTX 4000 Ada Graphics Accelerator, L40 48GB Accelerator, A16 64GB Accelerator and L4 24GB Accelerator.

Intuitive Cloud Operating Experience: Simple, Self-service, and Automated
HPE ProLiant ML350 Gen11 servers are engineered for your hybrid world. The new ProLiant Gen11 servers simplify the way you control your business’s compute—from edge to cloud—with a cloud operating experience.
Transform business operations and pivot your team from reactive to proactive with global visibility and insight through a self-service console.
Automate tasks for efficiency in deployment, instant scalability, and seamless, simplified support and lifecycle management reducing tasks and shortening maintenance windows.
These experiences are engineered and built into all HPE ProLiant Gen11 servers, whether purchased as physical servers or consume as-a-service using HPE GreenLake as your compute and storage demands grow.
Simplify and secure server management from edge to cloud with HPE GreenLake for Compute Ops Management. HPE GreenLake for Compute Ops Management is an as-a-service compute management experience that delivers greater simplicity, agility, and speed across your entire compute landscape, globally.
Trusted Security by Design: Uncompromising, Fundamental, and Protected
HPE ProLiant ML350 Gen11 server uses the silicon root of trust to anchor the firmware of an HPE ASIC, creating an immutable fingerprint for the Intel Processor that must be matched exactly before the server will boot. This verifies that malicious code is contained, and healthy servers are protected.
HPE ProLiant Gen11 servers continuously protect healthy servers at the edge by providing rapid detection of security-compromised servers, even to the point of not allowing them to boot if it identifies and contains malicious code, with IDevID certificates installed by default.
HPE ProLiant Gen11 servers provide automated recovery from a security event, including restoration of validated firmware, and facilitating recovery of the operating system, application, data connections, and providing a fast path to bring a server back online and into normal operations.
From silicon to software, from factory to cloud, and from generation to generation, HPE ProLiant Gen11 is engineered with a fundamental security approach to defend against increasingly complex threats through an uncompromising commitment to constant security advancements that are built into our DNA.

Optimized Performance for your Workloads: Accelerated, Open, and Efficient
The HPE ProLiant ML350 Gen11 server is an excellent choice for Compute and data storage demanding workloads (AI, ML, telco, DB analytics,) requiring high core count, GPU capabilities, and network and I/O bandwidth.
Harness major compute performance. The HPE ProLiant ML350 Gen11 server is powered by 4th and 5th Gen Intel® Xeon® Scalable Processors that support up to 64 cores (128 cores per server) at 350W TDP.
Enjoy advanced data transfer rates and higher network speeds from the PCIe Gen5 serial expansion bus, with up to 4 x16 PCIe Gen5 and 2 x16 OCP slots to improve I/O throughput and reduce latency.
Utilize 32 DIMM channels for up to 8 TB DDR5 memory with increased memory bandwidth and performance, and lower power requirements
Industry-leading Services and Ease of Deployment
The HPE ProLiant ML350 Gen11 server comes with a complete set of HPE Services, delivering confidence, reducing risk, and helping customers realize agility and stability.
HPE Services simplify all stages of the IT journey. Advisory and Transformation Services professionals understand customer challenges and design an effective solution. Professional Services enable rapid deployment of solutions and Operational Services provide ongoing support.
Services provided under Operational Services include: HPE Flexible Capacity, HPE Datacenter Care, HPE Infrastructure Automation, HPE Campus Care, HPE Proactive Services and multi-vendor coverage.
HPE IT investment solutions help you transform to a digital business with IT economics that align to your business goals.
Benefit from real-time operational feedback on server performance plus recommendations for fine-tuning BIOS settings to customize for changing business needs. -
Category Details Model HPE ProLiant ML350 Gen11 4416+ Processor Intel Xeon Silver 4416+ (20-core, 2.00 GHz) Memory 32 GB DDR5 Smart Memory (1x32 GB, 4800 MT/s) Storage Controller HPE MR408i-o Gen11 x8 Lanes 4GB Cache Power Supply 1x HPE 1000W Flex Slot Titanium Hot Plug Power Supply Kit Expansion Slots 4 x8 PCIe 5.0 slots Form Factor 4U Tower Included Drives None standard; 8 SFF supported Security Features UEFI Secure Boot, Intel SGX, Immutable Silicon Root of Trust, TPM 2.0, Front bezel key-lock, optional Intrusion Cable, Padlock slot, Kensington Lock slot Network Controller Broadcom BCM5719 Ethernet 1Gb 4-port BASE-T OCP3 Adapter for HPE Cooling 8x Standard Fans Optical Drive Optional, none standard Warranty 3 years parts, 3 years labor, 3 years on-site support Weight 33.83 kg (74.582 lb) Dimensions 58.42 x 98.43 x 30.48 cm (23 x 38.75 x 12 in) -
Description Downloads HPE ProLiant ML350 Gen11 4416+ 2.0GHz 20‑core 1P 32GB‑R MR408i‑o 8SFF 1000W RPS Server | P53569-421 QuickSpecs Downloads
Book a Free Product Demo
Remote or on-site. No obligation.
Integrator or Installer?
Trade pricing, volume discounts, same-day collection.
Education & Public Sector Solutions
Exclusive pricing, flexible terms, and dedicated support for schools, universities, NHS, and government organisations.
LATEST CASE STUDIES
See more-
February 26, 2026Digital Menu Boards & High-Brightness Display for Karak Chaii, Southall
HOSPITALITY • DIGITAL MENU BOARDS43-inch 4K vivid-bright digital menu board installed by ScreenMoove, ceiling mounted for a clean finish, delivering sharper menu clarity, flexible content updates and reliable 24/7 commercial performance.ClientKarak ChaiiLocationSouthallSectorHospitalityInstallation DateFebruary 2026SolutionDigital Menu BoardsProducts43" Digital Signage Display -
January 22, 2026Digital Signage & Installation Service for A MANO, Orpington
RETAIL • Digital SignageWindow-facing 55-inch digital signage installed for A MANO in Orpington, delivering vivid-bright 800 cd/m2 visibility, CMS-controlled updates, and street-level brand impact and daily promotion.ClientA ManoLocationOrpingtonSectorHospitalityInstallation DateJanuary 2026SolutionDigital Signage + InstallationProducts55" Digital Signage Display -
January 14, 2026Digital Menu Boards with Custom Curved Mount Installation for Woodys, Andover
HOSPITALITY • DIGITAL MENU BOARDSFour-screen digital menu boards installed for Woodys in Andover, featuring a bespoke curved mounting layout and CMS-controlled content for a bold, immersive menu experience.ClientWoodysLocationAndoverSectorHospitality, QSRInstallation DateFebruary 2025SolutionDigital Menu Boards + CMSProducts43" Digital Menu Boards -
January 14, 2026Digital Signage & Freestanding Display for Naan Staap, Leicester
HOSPITALITY • DIGITAL MENU BOARDSMulti-screen digital menu boards and floor-to-ceiling ultra-high-brightness window display installed for Naan Staap in Leicester, delivering clear menus and strong street-level visibility impact.ClientNaan StaapLocationLeicesterSectorHospitality, QSRInstallation DateMay 2025SolutionMenu Boards + UHD DisplayProducts32" Menu Boards & 49" Display
Top Quality Store
Why it matters
Demonstrates consistently strong fulfilment, service, and post-sale experience across Google signals.
Great products and service! The guys always go above and beyond to make sure they supply you with the product that best fits your needs. I’ve been using Screen Moove for a number of years now and woul...
See moreScreen Moove went above and beyond for my requirements. Ordering system was super easy it just take 2 minutes to complete my order and I have received my tracking details right away after few minutes...
See moreMoe Khan, one of the team at Screen Move has been a fantastic help as we have navigated the process of choosing and buying screens and stands for our church. Helpful at every step of the way, patient...
See moreWe originally planned to purchase a cheap TV for our showrooms. After speaking with screen moove, we ended up investing in floorstanding displays across multiple retail sites and showrooms. The bright...
See moreI placed my order late at night but realized I had entered the wrong address. I immediately sent an email asking for it to be changed, not really expecting a reply until the next day. To my surprise,...
See moreI’ve been looking ultra high brightness display despite I checked everywhere I didn’t trust. They got my trust and I ordered. It arrived safely next day we have installed screen is awesome and high qu...
See moreThis is second time I used Screen Moove, I have bought double sided 55 inch display. The first order was a bit delayed I don't blame it might be happen, but customer service over the phone was excell...
See moreScreenmoove, perfect customer satisfaction from start to finish! Their customer service is incredibly helpful and fast. It’s amazing to be able to reach out and get quick solutions for any issue. We a...
See moreWe found that we needed a video call to work out the set up. The tech team at screenmoove were very very good. I would suggest that the instructions that come with the screen offer two key info. 1. Set...
See moreGreat experience with Jonathan Gray, previously I was looking for other companies and randomly ordering our needs from elsewhere. after I met with him, since 2024 we are keep purchasing from screen m...
See more
Need help choosing the right product?
Speak directly with a dedicated Screen Moove expert and get the right solution, first time.
Call us on: 020 8191 9223
Email us: info@screenmoove.com
Contact us
Simply complete our contact form, and we will promptly respond to your inquiries.
If you have any questions or enquiry, please fill out the form below with all of your details and we'll get back to you shortly.